The Kimmelman Lab located at the Perlmutter Cancer Center at NYU Langone Medical Center, in New York City is focused on the study of pancreatic cancer. As soon to be the second leading cause of cancer death in the United States, pancreatic cancer is highly refractory to all forms of treatment and novel approaches are urgently needed. Our lab is focused on understanding the complex biology of this deadly cancer to develop novel therapeutic approaches as well as to promote response to exisiting agents such as chemotherapy and radiation. Specifically, we have taken a comprehensive approach to study the altered cellular metabolism of pancreatic cancers. This includes metabolic scavenging pathways such as autophagy.